CHRNA1
Gene Ontology Biological Process
- cation transmembrane transport [ISO]
- cation transport [ISO]
- muscle cell cellular homeostasis [ISO]
- musculoskeletal movement [ISO]
- neuromuscular junction development [ISO]
- neuromuscular process [ISO]
- neuromuscular synaptic transmission [ISO]
- neuron cellular homeostasis [ISO]
- neuronal action potential [ISO]
- regulation of membrane potential [IGI, ISO]
- skeletal muscle contraction [ISO]
- skeletal muscle tissue growth [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRIM63
Gene Ontology Biological Process
- cellular response to dexamethasone stimulus [IDA]
- muscle contraction [ISA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein ubiquitination [IDA]
- regulation of gene expression [IMP]
- response to denervation involved in regulation of muscle adaptation [IDA]
- response to electrical stimulus involved in regulation of muscle adaptation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.
Muscle atrophy is a process of muscle wasting induced under a series of catabolic stress conditions, such as denervation, disuse, cancer cachexia, heart and renal failure, AIDS, and aging. Neuromuscular junctions (NMJs), the synapses between motor neurons and muscle fibers undergo major changes in atrophying muscles, ranging from mild morphological alterations to complete disintegration. In this study, we hypothesized that ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID