BAIT

CHRNA1

AI385656, AI608266, Achr-1, Acra, RP23-325P5.2
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Mus musculus
PREY

CHRNA1

AI385656, AI608266, Achr-1, Acra, RP23-325P5.2
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways.

Rudolf R, Bogomolovas J, Strack S, Choi KR, Khan MM, Wagner A, Brohm K, Hanashima A, Gasch A, Labeit D, Labeit S

Muscle atrophy is a process of muscle wasting induced under a series of catabolic stress conditions, such as denervation, disuse, cancer cachexia, heart and renal failure, AIDS, and aging. Neuromuscular junctions (NMJs), the synapses between motor neurons and muscle fibers undergo major changes in atrophying muscles, ranging from mild morphological alterations to complete disintegration. In this study, we hypothesized that ... [more]

Age (Dordr) Sep. 06, 2012; 0(0); [Pubmed: 22956146]

Throughput

  • Low Throughput

Curated By

  • BioGRID