BAIT
ASCL1
ASH1, HASH1, MASH1, bHLHa46
achaete-scute family bHLH transcription factor 1
GO Process (17)
GO Function (8)
GO Component (1)
Gene Ontology Biological Process
- Notch signaling pathway [IDA]
- cerebral cortex GABAergic interneuron differentiation [IEP]
- lung epithelial cell differentiation [NAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of neuron differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurogenesis [IDA]
- noradrenergic neuron development [ISS]
- noradrenergic neuron fate commitment [IMP]
- positive regulation of neuron differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of gene expression [ISS]
- response to retinoic acid [IEP]
- sympathetic ganglion development [ISS]
- sympathetic nervous system development [NAS]
- ventral spinal cord interneuron fate commitment [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding transcription factor activity [ISS]
- DNA binding [ISS]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding transcription factor activity [ISS]
Homo sapiens
PREY
MEF2D
RP11-98G7.2
myocyte enhancer factor 2D
GO Process (4)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [IPI]
- histone deacetylase binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family.
Establishment of skeletal muscle and neural cell types is controlled by families of myogenic and neurogenic basic helix-loop-helix (bHLH) proteins, respectively. Myogenic bHLH proteins have been shown to activate skeletal muscle transcription in collaboration with members of the myocyte enhancer factor-2 (MEF2) family of MCM1-agamous-deficiens-serum response factor (MADS)-box transcription factors, which are expressed in differentiated myocytes and neurons. Here, we ... [more]
J. Biol. Chem. Oct. 25, 1996; 271(43);26659-63 [Pubmed: 8900141]
Throughput
- Low Throughput
Curated By
- BioGRID