SELL
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCQ
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- innate immune response [TAS]
- intracellular signal transduction [NAS]
- membrane protein ectodomain proteolysis [ISS]
- negative regulation of T cell apoptotic process [IMP]
- negative regulation of insulin receptor signaling pathway [IMP]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [ISS]
- positive regulation of T-helper 17 type immune response [ISS]
- positive regulation of T-helper 2 cell activation [ISS]
- positive regulation of interleukin-17 production [ISS]
- positive regulation of interleukin-4 production [ISS]
- protein ubiquitination [TAS]
- regulation of cell growth [NAS]
- regulation of platelet aggregation [ISS]
- regulation of rhodopsin mediated signaling pathway [TAS]
- regulation of transcription, DNA-templated [ISS]
- rhodopsin mediated signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor.
The leukocyte adhesion molecule L-selectin has an important role in the initial steps of leukocyte extravasation during inflammation and lymphocyte homing. Its cytoplasmic domain is involved in signal transduction after L-selectin cross-linking and in the regulation of receptor binding activity in response to intracellular signals. However, the signaling events occurring at the level of the receptor are largely unknown. This ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID