HSP90AB1
Gene Ontology Biological Process
- cellular response to interleukin-4 [IDA]
- negative regulation of neuron apoptotic process [ISO]
- placenta development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein import into nucleus, translocation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
- ATP binding [ISO]
- CTP binding [ISO]
- GTP binding [ISO]
- MHC class II protein complex binding [ISO]
- UTP binding [ISO]
- dATP binding [ISO]
- double-stranded RNA binding [ISO]
- ion channel binding [ISO]
- kinase binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sulfonylurea receptor binding [ISO]
Gene Ontology Cellular Component
IRF3
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IDA]
- defense response to virus [IMP]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of defense response to virus by host [IDA]
- negative regulation of interferon-beta biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of interferon-alpha production [IMP]
- positive regulation of interferon-beta production [IMP, TAS]
- positive regulation of type I interferon-mediated signaling pathway [IMP]
- programmed necrotic cell death [IMP]
- response to bacterium [IDA]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- type I interferon biosynthetic process [IGI]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells.
Interferon regulatory factor 3 (IRF3) plays a crucial role in mediating cellular responses to virus intrusion. The protein kinase TBK1 is a key regulator inducing phosphorylation of IRF3. The regulatory mechanisms during IRF3 activation remain poorly characterized. In the present study, we have identified by yeast two-hybrid approach a specific interaction between IRF3 and chaperone heat-shock protein of 90 kDa ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID