A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.

Shim YS, Choi Y, Kang K, Cho K, Oh S, Lee J, Grewal SI, Lee D

The positioning of the nucleosome by ATP-dependent remodellers provides the fundamental chromatin environment for the regulation of diverse cellular processes acting on the underlying DNA. Recently, genome-wide nucleosome mapping has revealed more detailed information on the chromatin-remodelling factors. Here, we report that the Schizosaccharomyces pombe CHD remodeller, Hrp3, is a global regulator that drives proper nucleosome positioning and nucleosome stability. ... [more]

EMBO J. Nov. 28, 2012; 31(23);4375-87 [Pubmed: 22990236]

Throughput

Low Throughput

Ontology Terms

phenotype: rna accumulation (APO:0000224)

Additional Notes

double mutants show a synergistic increase in antisense transcripts
double mutants show an increase in centromeric repeat transcript levels

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
ALP13 HRP3	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Ryan CJ (2012)	High	-8.5732	BioGRID	794122

Curated By

BioGRID

Interaction Summary

HRP3

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP-dependent DNA helicase activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

ALP13