A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The Ubiquitin Associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is Essential for the Recognition of Ubiquitin Proteasome System Substrates Both in vitro and in vivo.

Medina B, Paraskevopoulos K, Boehringer J, Sznajder A, Robertson M, Endicott J, Gordon C

The ubiquitin proteasome system (UPS) is essential for maintaining a functional cell. Not only does it remove incorrectly folded proteins, it also regulates protein levels to ensure their appropriate spatial and temporal distribution. Proteins marked for degradation by the addition of K48-linked ubiquitin (Ub) chains are recognised by shuttle factors and transported to the 26S proteasome. One of these shuttle ... [more]

J. Biol. Chem. Oct. 04, 2012; 0(0); [Pubmed: 23038266]

Throughput

Low Throughput

Ontology Terms

phenotype: heat sensitivity (APO:0000147)
phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

RHP23

Gene Ontology Biological Process

Gene Ontology Molecular Function

damaged DNA binding [ISO]polyubiquitin binding [TAS]ubiquitin binding [IDA]

Gene Ontology Cellular Component

PUS1