Rad23 homolog Rhp23
Schizosaccharomyces pombe (972h)


lps1, SPCC126.03
tRNA pseudouridine synthase Lsp1
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


The Ubiquitin Associated (UBA) 1 domain of Schizosaccharomyces pombe Rhp23 is Essential for the Recognition of Ubiquitin Proteasome System Substrates Both in vitro and in vivo.

Medina B, Paraskevopoulos K, Boehringer J, Sznajder A, Robertson M, Endicott J, Gordon C

The ubiquitin proteasome system (UPS) is essential for maintaining a functional cell. Not only does it remove incorrectly folded proteins, it also regulates protein levels to ensure their appropriate spatial and temporal distribution. Proteins marked for degradation by the addition of K48-linked ubiquitin (Ub) chains are recognised by shuttle factors and transported to the 26S proteasome. One of these shuttle ... [more]

J. Biol. Chem. Oct. 04, 2012; 0(0); [Pubmed: 23038266]


  • Low Throughput

Ontology Terms

  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: inviable (APO:0000112)

Curated By

  • BioGRID