VANGL2
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- Wnt signaling pathway, planar cell polarity pathway [IGI, IMP]
- anterior/posterior pattern specification [IMP]
- apical protein localization [IMP]
- cardiac vascular smooth muscle cell differentiation [TAS]
- cell migration involved in kidney development [IMP]
- cochlea development [IGI]
- cochlea morphogenesis [IGI, IMP]
- convergent extension involved in axis elongation [IMP]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- digestive tract morphogenesis [IGI]
- epicardial cell to mesenchymal cell transition [TAS]
- establishment of body hair planar orientation [IMP]
- establishment of epithelial cell polarity [TAS]
- establishment of planar polarity [IGI, IMP]
- establishment of planar polarity involved in neural tube closure [IMP]
- establishment or maintenance of epithelial cell apical/basal polarity [IMP]
- glomerulus development [IMP]
- hair follicle development [IMP]
- heart looping [IMP]
- inner ear receptor cell development [IGI]
- inner ear receptor stereocilium organization [IGI, IMP]
- kidney morphogenesis [IMP]
- lateral sprouting involved in lung morphogenesis [IMP]
- membranous septum morphogenesis [IGI]
- muscular septum morphogenesis [IGI]
- neural tube closure [IGI, IMP]
- non-canonical Wnt signaling pathway [IMP]
- nonmotile primary cilium assembly [IGI]
- orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- outflow tract septum morphogenesis [TAS]
- patterning of blood vessels [TAS]
- planar cell polarity pathway involved in axis elongation [IGI]
- planar cell polarity pathway involved in heart morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- planar dichotomous subdivision of terminal units involved in lung branching morphogenesis [IMP]
- positive regulation of JUN kinase activity [IGI]
- post-anal tail morphogenesis [IMP]
- regulation of Wnt signaling pathway [IMP]
- regulation of actin cytoskeleton organization [IMP]
- regulation of establishment of planar polarity [IGI]
- somatic stem cell division [IMP]
- somatic stem cell maintenance [IMP]
- wound healing [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DVL2
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO, NAS]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO]
- canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [ISO]
- cellular protein localization [IDA]
- cochlea morphogenesis [IGI]
- convergent extension involved in neural plate elongation [IGI, IMP]
- convergent extension involved in organogenesis [IGI]
- heart development [IMP]
- heart morphogenesis [IGI]
- neural tube closure [IMP]
- non-canonical Wnt signaling pathway [ISO]
- outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI, IMP]
- positive regulation of JUN kinase activity [IDA, ISO]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein tyrosine kinase activity [IGI]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- segment specification [IMP]
- segmentation [IGI]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.
Mammalian Vangl1 and Vangl2 are highly conserved membrane proteins that have evolved from a single ancestral protein Strabismus/Van Gogh found in Drosophila. Mutations in the Vangl2 gene cause a neural tube defect (craniorachischisis) characteristic of the looptail (Lp) mouse. Studies in model organisms indicate that Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DVL2 VANGL2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DVL2 VANGL2 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 505260 | |
| VANGL2 DVL2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 504990 |
Curated By
- BioGRID