ROR2
Gene Ontology Biological Process
- JNK cascade [IDA]
- Wnt signaling pathway, calcium modulating pathway [IPI]
- Wnt signaling pathway, planar cell polarity pathway [IMP]
- cartilage condensation [IMP]
- cell differentiation [IMP]
- embryonic genitalia morphogenesis [IMP]
- inner ear morphogenesis [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [ISO]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell migration [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- skeletal system development [IMP]
- somitogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNT5A
Gene Ontology Biological Process
- JNK cascade [IDA]
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- activation of JUN kinase activity [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- ameboidal-type cell migration [IMP]
- anterior/posterior axis specification, embryo [IDA]
- anterior/posterior pattern specification [IMP]
- axis elongation [IMP]
- axon guidance [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- cell fate commitment [IBA]
- cell migration [IGI, IMP]
- cell-cell signaling [TAS]
- cellular protein localization [IMP, ISO]
- cellular response to molecule of bacterial origin [IDA]
- cervix development [IMP]
- cochlea morphogenesis [IGI, IMP]
- convergent extension [IMP]
- convergent extension involved in organogenesis [IGI]
- determination of left/right symmetry [IMP]
- development of primary male sexual characteristics [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- embryo development [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- embryonic skeletal system development [ISO]
- epithelial cell proliferation involved in mammary gland duct elongation [IDA]
- establishment of planar polarity [IMP]
- face development [ISO]
- genitalia development [ISO]
- heart looping [IGI]
- hematopoietic stem cell proliferation [IDA, IMP, ISO]
- hindgut morphogenesis [IMP]
- hypophysis morphogenesis [IMP]
- inner ear morphogenesis [IDA, IMP]
- lateral sprouting involved in mammary gland duct morphogenesis [IDA]
- limb morphogenesis [IMP]
- lung development [IMP]
- male gonad development [IMP]
- mammary gland branching involved in thelarche [IDA]
- mesenchymal-epithelial cell signaling [IMP]
- midgut development [IMP]
- morphogenesis of an epithelium [IMP]
- negative chemotaxis [IGI]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of axon extension involved in axon guidance [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of mesenchymal cell proliferation [ISO]
- negative regulation of prostatic bud formation [IMP]
- negative regulation of synapse assembly [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- neuron projection morphogenesis [IDA]
- non-canonical Wnt signaling pathway [IDA]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- olfactory bulb interneuron development [IMP]
- organ morphogenesis [TAS]
- palate development [ISO]
- pericardium morphogenesis [IGI]
- planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IMP]
- planar cell polarity pathway involved in cardiac right atrium morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IMP]
- planar cell polarity pathway involved in outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in pericardium morphogenesis [IMP]
- planar cell polarity pathway involved in ventricular septum morphogenesis [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cGMP metabolic process [ISO]
- positive regulation of cartilage development [IDA, IMP]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of chemokine biosynthetic process [ISO]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion involved in immune response [ISO]
- positive regulation of endocytosis [IDA]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA, ISO]
- positive regulation of interleukin-6 production [IDA, ISO]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of macrophage activation [ISO]
- positive regulation of macrophage cytokine production [ISO]
- positive regulation of meiosis [IGI]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of ossification [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of peptidyl-threonine phosphorylation [IGI]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of response to cytokine stimulus [ISO]
- positive regulation of thymocyte apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- protein phosphorylation [IGI]
- regulation of branching involved in mammary gland duct morphogenesis [IDA, IGI]
- regulation of protein localization [IDA]
- signal transduction [TAS]
- somitogenesis [IGI]
- tube closure [IMP]
- type B pancreatic cell development [IMP]
- urinary bladder development [IMP]
- uterus development [IMP]
- vagina development [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
The Wnts comprise a large class of secreted proteins that control essential developmental processes such as embryonic patterning, cell growth, migration, and differentiation. In the most well-understood "canonical" Wnt signaling pathway, Wnt binding to Frizzled receptors induces beta-catenin protein stabilization and entry into the nucleus, where it complexes with T-cell factor/lymphoid enhancer factor transcription factors to affect the transcription of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ROR2 WNT5A | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 521977 | |
| ROR2 WNT5A | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID