BAIT
SFRP1
2210415K03Rik, AW011917, AW107218, AW742929, sFRP-1
secreted frizzled-related protein 1
GO Process (75)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- actin cytoskeleton organization [ISO]
- anterior/posterior pattern specification [IGI]
- bone trabecula formation [IMP]
- canonical Wnt signaling pathway [ISO]
- cellular response to X-ray [IDA]
- cellular response to estrogen stimulus [IDA, ISO]
- cellular response to fibroblast growth factor stimulus [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to heparin [ISO]
- cellular response to tumor necrosis factor [ISO]
- convergent extension involved in somitogenesis [IGI]
- development of primary male sexual characteristics [IGI]
- digestive tract morphogenesis [IGI]
- dorsal/ventral axis specification [ISO]
- female gonad development [IGI]
- hematopoietic progenitor cell differentiation [ISO]
- hematopoietic stem cell differentiation [ISO]
- hemopoiesis [IMP]
- male gonad development [IGI]
- negative regulation of B cell differentiation [IMP, ISO]
- negative regulation of BMP signaling pathway [IGI]
- negative regulation of JUN kinase activity [IGI]
- negative regulation of Wnt signaling pathway [IGI, ISO]
- negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of bone remodeling [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, ISO]
- negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast apoptotic process [ISO]
- negative regulation of fibroblast proliferation [ISO]
- negative regulation of gene expression [IMP, ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of ossification [IMP, ISO]
- negative regulation of osteoblast differentiation [IMP]
- negative regulation of osteoblast proliferation [IMP, ISO]
- negative regulation of osteoclast differentiation [IMP, ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of planar cell polarity pathway involved in axis elongation [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neural crest cell fate commitment [IMP]
- neural tube closure [IGI]
- neural tube development [IGI]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of fibroblast apoptotic process [ISO]
- positive regulation of non-canonical Wnt signaling pathway [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis [IMP]
- proteolysis [ISO]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of cell cycle process [ISO]
- regulation of establishment of planar polarity [IGI]
- regulation of ossification [ISO]
- response to drug [IDA, ISO]
- response to organic cyclic compound [ISO]
- somatic stem cell maintenance [IMP]
- somitogenesis [IGI]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
WNT5A
8030457G12Rik, Wnt-5a, RP24-345B5.1
wingless-type MMTV integration site family, member 5A
GO Process (126)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- JNK cascade [IDA]
- Wnt signaling pathway [IGI, ISO]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP, ISO]
- Wnt signaling pathway, planar cell polarity pathway [IDA, IGI, IMP, ISO]
- activation of JUN kinase activity [ISO]
- activation of MAPK activity [ISO]
- activation of protein kinase B activity [ISO]
- ameboidal-type cell migration [IMP]
- anterior/posterior axis specification, embryo [IDA]
- anterior/posterior pattern specification [IMP]
- axis elongation [IMP]
- axon guidance [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- cell fate commitment [IBA]
- cell migration [IGI, IMP]
- cell-cell signaling [TAS]
- cellular protein localization [IMP, ISO]
- cellular response to molecule of bacterial origin [IDA]
- cervix development [IMP]
- cochlea morphogenesis [IGI, IMP]
- convergent extension [IMP]
- convergent extension involved in organogenesis [IGI]
- determination of left/right symmetry [IMP]
- development of primary male sexual characteristics [IMP]
- digestive tract morphogenesis [IMP]
- dopaminergic neuron differentiation [IGI, IMP]
- embryo development [IMP]
- embryonic digit morphogenesis [IMP]
- embryonic limb morphogenesis [IMP]
- embryonic skeletal system development [ISO]
- epithelial cell proliferation involved in mammary gland duct elongation [IDA]
- establishment of planar polarity [IMP]
- face development [ISO]
- genitalia development [ISO]
- heart looping [IGI]
- hematopoietic stem cell proliferation [IDA, IMP, ISO]
- hindgut morphogenesis [IMP]
- hypophysis morphogenesis [IMP]
- inner ear morphogenesis [IDA, IMP]
- lateral sprouting involved in mammary gland duct morphogenesis [IDA]
- limb morphogenesis [IMP]
- lung development [IMP]
- male gonad development [IMP]
- mammary gland branching involved in thelarche [IDA]
- mesenchymal-epithelial cell signaling [IMP]
- midgut development [IMP]
- morphogenesis of an epithelium [IMP]
- negative chemotaxis [IGI]
- negative regulation of BMP signaling pathway [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of axon extension involved in axon guidance [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of epithelial cell proliferation [IDA, IMP]
- negative regulation of fat cell differentiation [ISO]
- negative regulation of fibroblast growth factor receptor signaling pathway [IMP]
- negative regulation of mesenchymal cell proliferation [ISO]
- negative regulation of prostatic bud formation [IMP]
- negative regulation of synapse assembly [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IGI]
- neural tube development [IGI]
- neuron projection morphogenesis [IDA]
- non-canonical Wnt signaling pathway [IDA]
- non-canonical Wnt signaling pathway via JNK cascade [IMP]
- olfactory bulb interneuron development [IMP]
- organ morphogenesis [TAS]
- palate development [ISO]
- pericardium morphogenesis [IGI]
- planar cell polarity pathway involved in cardiac muscle tissue morphogenesis [IMP]
- planar cell polarity pathway involved in cardiac right atrium morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IMP]
- planar cell polarity pathway involved in outflow tract morphogenesis [IMP]
- planar cell polarity pathway involved in pericardium morphogenesis [IMP]
- planar cell polarity pathway involved in ventricular septum morphogenesis [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T cell chemotaxis [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cGMP metabolic process [ISO]
- positive regulation of cartilage development [IDA, IMP]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of cell-cell adhesion mediated by cadherin [IDA]
- positive regulation of chemokine biosynthetic process [ISO]
- positive regulation of cytokine production [IDA]
- positive regulation of cytokine secretion involved in immune response [ISO]
- positive regulation of endocytosis [IDA]
- positive regulation of endothelial cell migration [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-1 beta secretion [IDA, ISO]
- positive regulation of interleukin-6 production [IDA, ISO]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of macrophage activation [ISO]
- positive regulation of macrophage cytokine production [ISO]
- positive regulation of meiosis [IGI]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of ossification [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of peptidyl-threonine phosphorylation [IGI]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of response to cytokine stimulus [ISO]
- positive regulation of thymocyte apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of type I interferon-mediated signaling pathway [ISO]
- post-anal tail morphogenesis [IGI, IMP]
- primitive streak formation [IGI]
- protein phosphorylation [IGI]
- regulation of branching involved in mammary gland duct morphogenesis [IDA, IGI]
- regulation of protein localization [IDA]
- signal transduction [TAS]
- somitogenesis [IGI]
- tube closure [IMP]
- type B pancreatic cell development [IMP]
- urinary bladder development [IMP]
- uterus development [IMP]
- vagina development [IMP]
- wound healing [ISO]
Gene Ontology Molecular Function- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- cytokine activity [IDA]
- frizzled binding [IPI, ISO]
- frizzled-2 binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- receptor binding [IPI, TAS]
- receptor tyrosine kinase-like orphan receptor binding [ISO]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium.
Epithelial tubular morphogenesis leading to alteration of organ shape has important physiological consequences. However, little is known regarding the mechanisms that govern epithelial tube morphogenesis. Here, we show that inactivation of Sfrp1 and Sfrp2 leads to reduction in fore-stomach length in mouse embryos, which is enhanced in the presence of the Sfrp5 mutation. In the mono-cell layer of fore-stomach epithelium, ... [more]
PLoS Genet. Mar. 01, 2009; 5(3);e1000427 [Pubmed: 19300477]
Throughput
- Low Throughput
Curated By
- BioGRID