EN1
Gene Ontology Biological Process
- dorsal/ventral pattern formation [IMP]
- embryonic forelimb morphogenesis [IGI]
- embryonic limb morphogenesis [IGI, IMP]
- hindbrain development [IGI]
- limb development [IMP]
- midbrain development [IGI]
- midbrain-hindbrain boundary development [IMP]
- multicellular organism growth [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neuron development [IGI, IMP]
- neuron differentiation [IGI]
- pigmentation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- proximal/distal pattern formation [IMP]
- regulation of gene expression [IGI, IMP]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
DKK1
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- cell morphogenesis involved in differentiation [IMP]
- embryonic limb morphogenesis [IGI]
- endoderm development [IMP]
- endoderm formation [IDA]
- extracellular negative regulation of signal transduction [ISO]
- face morphogenesis [IMP]
- forebrain development [IGI]
- hair follicle development [IDA]
- head morphogenesis [IGI]
- mesoderm formation [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- negative regulation of cardiac muscle cell differentiation [ISO]
- negative regulation of mesodermal cell fate specification [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- negative regulation of receptor activity [ISO]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [IDA]
- regulation of Wnt signaling pathway [IMP]
- regulation of endodermal cell fate specification [ISO]
- regulation of receptor internalization [ISO]
- response to retinoic acid [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
En1 and Wnt7a interact with Dkk1 during limb development in the mouse.
Wnt signaling plays an essential role in induction and development of the limb. Missing digits are one consequence of the reduced Wnt signaling in Wnt7a null mice, while extra digits result from excess Wnt signaling in mice null for the Wnt antagonist Dkk1. The extra digits and expanded apical ectodermal ridge (AER) of Dkk1-deficient mice closely resemble En1 null mice. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DKK1 EN1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID