BAIT
WNT7A
AI849442, Wnt-7a, px, tw
wingless-type MMTV integration site family, member 7A
GO Process (55)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- Wnt signaling pathway involved in wound healing, spreading of epidermal cells [ISO]
- angiogenesis [IGI]
- asymmetric protein localization [IDA]
- canonical Wnt signaling pathway [IGI, ISO]
- cartilage condensation [ISO]
- cartilage development [IDA]
- cell fate commitment [IBA]
- cell proliferation in forebrain [ISO]
- cell-cell signaling [TAS]
- central nervous system vasculogenesis [IGI]
- cerebellar granule cell differentiation [IDA]
- chondrocyte differentiation [ISO]
- dorsal/ventral pattern formation [IMP]
- embryonic axis specification [ISO]
- embryonic digit morphogenesis [ISO]
- embryonic forelimb morphogenesis [IGI, IMP, ISO]
- embryonic hindlimb morphogenesis [IGI, ISO]
- embryonic limb morphogenesis [IGI]
- establishment of cell polarity [IDA]
- forelimb morphogenesis [IMP]
- hindlimb morphogenesis [IMP]
- limb development [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of neurogenesis [ISO]
- neurotransmitter secretion [IGI]
- non-canonical Wnt signaling pathway [IGI]
- organ morphogenesis [TAS]
- oviduct development [IMP]
- palate development [ISO]
- positive regulation of JNK cascade [IBA, ISO]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell proliferation [ISO]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of epithelial cell proliferation involved in wound healing [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of receptor activity [ISO]
- positive regulation of synapse assembly [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of axon diameter [IDA]
- regulation of axonogenesis [IDA]
- regulation of cell proliferation [IMP]
- reproductive structure development [IMP]
- response to estrogen [IMP]
- signal transduction [TAS]
- skeletal muscle satellite cell activation [IDA]
- skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [IDA]
- skeletal system morphogenesis [IMP]
- skin morphogenesis [IMP]
- somatic stem cell division [IDA]
- somatic stem cell maintenance [IMP]
- stem cell development [ISO]
- synapse organization [IGI, IMP]
- uterus development [IMP]
- uterus morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DKK1
mdkk-1
dickkopf homolog 1 (Xenopus laevis)
GO Process (28)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- Wnt signaling pathway involved in somitogenesis [IGI]
- cell morphogenesis involved in differentiation [IMP]
- embryonic limb morphogenesis [IGI]
- endoderm development [IMP]
- endoderm formation [IDA]
- extracellular negative regulation of signal transduction [ISO]
- face morphogenesis [IMP]
- forebrain development [IGI]
- hair follicle development [IDA]
- head morphogenesis [IGI]
- mesoderm formation [IDA]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI, IMP, ISO]
- negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment [ISO]
- negative regulation of cardiac muscle cell differentiation [ISO]
- negative regulation of mesodermal cell fate specification [ISO]
- negative regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- negative regulation of peptidyl-serine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- negative regulation of receptor activity [ISO]
- negative regulation of skeletal muscle tissue development [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway [IDA]
- regulation of Wnt signaling pathway [IMP]
- regulation of endodermal cell fate specification [ISO]
- regulation of receptor internalization [ISO]
- response to retinoic acid [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
En1 and Wnt7a interact with Dkk1 during limb development in the mouse.
Wnt signaling plays an essential role in induction and development of the limb. Missing digits are one consequence of the reduced Wnt signaling in Wnt7a null mice, while extra digits result from excess Wnt signaling in mice null for the Wnt antagonist Dkk1. The extra digits and expanded apical ectodermal ridge (AER) of Dkk1-deficient mice closely resemble En1 null mice. ... [more]
Dev. Biol. Aug. 01, 2004; 272(1);134-44 [Pubmed: 15242796]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DKK1 WNT7A | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID