BAIT
NFKBIA
RL/IF-1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
GO Process (22)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [IMP, ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Notch signaling pathway [ISO]
- negative regulation of lipid storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of myeloid cell differentiation [ISO]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein import into nucleus, translocation [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to muramyl dipeptide [ISO]
- response to muscle stretch [ISO]
- toll-like receptor 4 signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GJA1
AU042049, AW546267, Cnx43, Cx43, Cx43alpha1, Gja-1, Npm1, connexin43
gap junction protein, alpha 1
GO Process (58)
GO Function (10)
GO Component (24)
Gene Ontology Biological Process
- ATP transport [ISO]
- adult heart development [IMP]
- apoptotic process [ISO]
- atrial ventricular junction remodeling [IGI]
- blood vessel morphogenesis [IMP]
- cardiac conduction [IMP]
- cell communication [ISO]
- cell communication by chemical coupling [IDA]
- cell communication by electrical coupling [IDA, ISO]
- cell-cell junction organization [IMP]
- cell-cell signaling [IDA, ISO]
- chronic inflammatory response [ISO]
- embryonic digit morphogenesis [IMP]
- embryonic heart tube development [IMP]
- epicardial cell to mesenchymal cell transition [TAS]
- epithelial cell maturation [IMP]
- establishment of epithelial cell polarity [TAS]
- heart development [IMP]
- heart looping [IMP]
- in utero embryonic development [IMP]
- lens development in camera-type eye [IMP]
- milk ejection [IMP]
- negative regulation of DNA biosynthetic process [ISO]
- negative regulation of cardiac muscle cell proliferation [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of endothelial cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of wound healing [ISO]
- neuron migration [IMP]
- neuron projection morphogenesis [ISO]
- osteoblast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of behavioral fear response [ISO]
- positive regulation of cell communication by chemical coupling [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of glomerular filtration [ISO]
- positive regulation of insulin secretion [ISO]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of protein catabolic process [ISO]
- positive regulation of striated muscle tissue development [IMP]
- positive regulation of vasoconstriction [ISO]
- positive regulation of vasodilation [ISO]
- protein oligomerization [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of blood vessel remodeling [TAS]
- regulation of bone mineralization [IMP]
- regulation of bone remodeling [IMP]
- regulation of calcium ion transport [ISO]
- regulation of heart contraction [IMP]
- regulation of tight junction assembly [ISO]
- regulation of ventricular cardiac muscle cell membrane depolarization [IGI, IMP]
- regulation of ventricular cardiac muscle cell membrane repolarization [IGI, IMP]
- response to pH [ISO]
- signal transduction [ISO]
- skeletal muscle tissue regeneration [IDA]
- transmembrane transport [IDA, ISO]
- vascular transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- apical plasma membrane [IDA]
- cell junction [IDA]
- cell-cell junction [IDA]
- connexon complex [ISO]
- contractile fiber [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- early endosome [ISO]
- endosome [ISO]
- extracellular vesicular exosome [ISO]
- fascia adherens [IDA, ISO]
- focal adhesion [ISO]
- gap junction [IDA, ISO]
- intercalated disc [IDA, ISO]
- intermediate filament [IDA]
- late endosome [ISO]
- lateral plasma membrane [IDA]
- lysosome [ISO]
- membrane [IDA, ISO]
- membrane raft [ISO]
- mitochondrial outer membrane [ISO]
- multivesicular body [ISO]
- plasma membrane [IDA, ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-kappa B signaling.
In this study, we examined effects of the three-dimensional (3D)-clinorotation, a simulated-model of microgravity, on proliferation/differentiation of rat myoblastic L6 cells. Differentiation of L6 cells into myotubes was significantly disturbed in the 3D-clinorotation culture system, although the 3D-clinorotation had no effect on the proliferation. The 3D-clinorotation also suppressed the expression of myogenesis marker proteins, such as myogenin and myosin heavy ... [more]
Biochim. Biophys. Acta Mar. 22, 2005; 1743(1);130-40 [Pubmed: 15777848]
Throughput
- Low Throughput
Curated By
- BioGRID