SKIL
Gene Ontology Biological Process
- blastocyst formation [IMP]
- cell cycle arrest [IMP]
- lens fiber cell differentiation [IDA]
- lymphocyte homeostasis [IMP]
- negative regulation of cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- negative regulation of transforming growth factor beta receptor signaling pathway [IMP, ISO]
- positive regulation of axonogenesis [ISO]
- positive regulation of extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- protein heterotrimerization [ISO]
- protein homotrimerization [ISO]
- response to growth factor [ISO]
- skeletal muscle tissue development [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IGI]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- SMAD binding [IBA, ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- transcription corepressor activity [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- SMAD binding [IBA, ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- transcription corepressor activity [ISO]
FZR1
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- activation of anaphase-promoting complex activity [ISO]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [ISO]
- lens fiber cell differentiation [IMP]
- negative regulation of cell aging [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of protein catabolic process [ISO]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The anaphase-promoting complex coordinates initiation of lens differentiation.
Lens development requires the precise coordination of cell division and differentiation. The mechanisms by which the differentiation program is initiated after cell cycle arrest remains not well understood. Cyclin-dependent kinase inhibitors (CKIs), such as p15 and p21, have been suggested to be critical components that inhibit G1 progression and therefore, their activation is necessary for quiescence and important for the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID