SIRT4
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISS]
- chromatin silencing [TAS]
- glutamine metabolic process [ISS]
- negative regulation of fatty acid oxidation [ISS]
- negative regulation of insulin secretion [IMP]
- peptidyl-lysine deacetylation [ISS]
- positive regulation of lipid biosynthetic process [ISS]
- protein ADP-ribosylation [ISS, TAS]
- tricarboxylic acid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLUD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Ribosylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, flies, and worms. Mammals have seven Sir2 homologs (SIRT1-7). We show that SIRT4 is a mitochondrial enzyme that uses NAD to ADP-ribosylate and downregulate glutamate dehydrogenase (GDH) activity. GDH is known to promote the metabolism of glutamate and glutamine, generating ATP, which promotes insulin secretion. Loss of SIRT4 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID