BAIT

CDK11

ppk23, SPBC18H10.15
serine/threonine protein kinase cdk11
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

PMC3

med27, prk1, SPAC17C9.05c
mediator complex subunit Pmc3/Med27
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Biochemical Activity (Phosphorylation)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Cdk11-CyclinL Controls the Assembly of the RNA Polymerase II Mediator Complex.

Drogat J, Migeot V, Mommaerts E, Mullier C, Dieu M, van Bakel H, Hermand D

The large Mediator (L-Mediator) is a general coactivator of RNA polymerase II transcription and is formed by the reversible association of the small Mediator (S-Mediator) and the kinase-module-harboring Cdk8. It is not known how the kinase module association/dissociation is regulated. We describe the fission yeast Cdk11-L-type cyclin pombe (Lcp1) complex and show that its inactivation alters the global expression profile ... [more]

Cell Rep Nov. 29, 2012; 2(5);1068-76 [Pubmed: 23122962]

Throughput

  • Low Throughput

Curated By

  • BioGRID