SH3GL2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SYNJ1
Gene Ontology Biological Process
- brain development [IEP]
- inositol phosphate dephosphorylation [ISO, ISS]
- learning [ISO]
- neurotransmitter transport [ISO, ISS]
- phosphatidylinositol dephosphorylation [ISO, ISS]
- phosphatidylinositol metabolic process [ISO, ISS]
- positive regulation of gliogenesis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- response to cytokine [IMP]
- response to retinoic acid [IMP]
- synaptic vesicle endocytosis [ISO, ISS]
- synaptic vesicle priming [ISO, ISS]
- synaptic vesicle transport [ISO, ISS]
- synaptic vesicle uncoating [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.
Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting synapses and stimulation-dependent dephosphorylation by calcineurin. Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptojanin 1 and regulates its function ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID