BAIT
CDK5
cyclin-dependent kinase 5
GO Process (70)
GO Function (13)
GO Component (18)
Gene Ontology Biological Process
- Schwann cell development [ISO]
- apoptotic process [ISO]
- associative learning [ISO]
- axon extension [TAS]
- axonogenesis [ISO]
- behavioral response to cocaine [ISO]
- calcium ion import [ISO]
- cell migration [ISO]
- cell-matrix adhesion [ISO]
- central nervous system development [TAS]
- central nervous system neuron development [ISO]
- cerebellar cortex development [ISO]
- cerebellar cortex formation [ISO]
- cerebellum development [ISO]
- cerebral cortex development [ISO]
- corpus callosum development [ISO]
- cortical actin cytoskeleton organization [IMP]
- dendrite morphogenesis [ISO]
- exocytosis [IMP]
- forebrain development [ISO]
- hippocampus development [ISO]
- intracellular protein transport [ISO]
- layer formation in cerebral cortex [ISO]
- motor neuron axon guidance [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of cell cycle [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein export from nucleus [ISO]
- negative regulation of protein ubiquitination [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of synaptic plasticity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neuron apoptotic process [IMP, ISO]
- neuron differentiation [IDA, ISO]
- neuron migration [ISO]
- neuron projection development [IMP]
- neuron projection morphogenesis [IMP]
- nucleocytoplasmic transport [IMP]
- oligodendrocyte differentiation [ISO]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [ISO]
- phosphorylation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of protein binding [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein targeting to membrane [ISO]
- positive regulation of receptor activity [ISO]
- protein autophosphorylation [IDA]
- protein localization to synapse [ISO]
- protein phosphorylation [IDA, ISO]
- receptor catabolic process [ISO]
- receptor clustering [ISO]
- regulated secretory pathway [IMP]
- regulation of cell migration [ISO]
- regulation of dendritic spine morphogenesis [ISO, ISS]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of postsynaptic membrane potential [ISO]
- regulation of synaptic plasticity [IMP]
- response to cocaine [ISO]
- response to wounding [IMP]
- sensory perception of pain [ISO]
- serine phosphorylation of STAT3 protein [ISO]
- skeletal muscle tissue development [IEP, ISO, TAS]
- synapse assembly [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [ISO]
- synaptic vesicle endocytosis [IMP]
- telencephalon development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- ErbB-2 class receptor binding [ISO, ISS]
- ErbB-3 class receptor binding [ISO, ISS]
- acetylcholine receptor activator activity [ISO, ISS]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- cytoskeletal protein binding [IPI]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [IDA]
- ErbB-2 class receptor binding [ISO, ISS]
- ErbB-3 class receptor binding [ISO, ISS]
- acetylcholine receptor activator activity [ISO, ISS]
- cyclin-dependent protein serine/threonine kinase activity [IDA]
- cytoskeletal protein binding [IPI]
- ephrin receptor binding [IPI]
- kinase activity [IDA]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IDA, ISO]
- tau-protein kinase activity [IDA]
Gene Ontology Cellular Component
- axon [IDA, ISO]
- cell [ISO]
- cell junction [TAS]
- cyclin-dependent protein kinase 5 holoenzyme complex [IDA]
- cytoplasm [IDA, ISO]
- cytoskeleton [IDA]
- cytosol [ISO]
- dendrite [IDA]
- filopodium [ISO]
- growth cone [IDA]
- intracellular [ISO]
- lamellipodium [ISO]
- membrane [IDA]
- neuromuscular junction [IDA]
- neuronal cell body [IDA]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
PREY
DNM1
Dnm
dynamin 1
GO Process (11)
GO Function (8)
GO Component (11)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- adult locomotory behavior [ISO]
- endocytosis [ISO]
- endosome organization [ISO]
- positive regulation of synaptic vesicle recycling [IMP]
- protein tetramerization [ISO]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IMP, ISO]
- sensory perception of sound [ISO]
- synaptic transmission, GABAergic [ISO]
- toxin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.
Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting synapses and stimulation-dependent dephosphorylation by calcineurin. Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptojanin 1 and regulates its function ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jan. 13, 2004; 101(2);546-51 [Pubmed: 14704270]
Throughput
- Low Throughput
Curated By
- BioGRID