PPP3CA
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- calcineurin-NFAT signaling cascade [ISO]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cellular response to drug [ISO]
- cellular response to glucose stimulus [IMP]
- dephosphorylation [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of calcium ion-dependent exocytosis [IC]
- negative regulation of insulin secretion [IMP]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of cardiac muscle hypertrophy in response to stress [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein dephosphorylation [IDA, ISO]
- protein import into nucleus [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of synaptic transmission [ISO]
- response to amphetamine [IEP]
- response to calcium ion [ISO, ISS]
- skeletal muscle fiber development [ISO]
- transition between fast and slow fiber [ISO]
Gene Ontology Molecular Function- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein serine/threonine phosphatase activity [IDA, TAS]
- calcium-dependent protein serine/threonine phosphatase activity [IDA]
- calmodulin binding [IDA, ISO]
- calmodulin-dependent protein phosphatase activity [ISO, ISS]
- drug binding [ISO]
- enzyme binding [ISO]
- phosphoprotein phosphatase activity [IDA, ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [IDA]
- protein serine/threonine phosphatase activity [IDA, TAS]
DNM1
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- adult locomotory behavior [ISO]
- endocytosis [ISO]
- endosome organization [ISO]
- positive regulation of synaptic vesicle recycling [IMP]
- protein tetramerization [ISO]
- receptor internalization [IMP]
- receptor-mediated endocytosis [IMP, ISO]
- sensory perception of sound [ISO]
- synaptic transmission, GABAergic [ISO]
- toxin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses.
Synaptojanin 1 is a polyphosphoinositide phosphatase concentrated in presynaptic nerve terminals, where it dephosphorylates a pool of phosphatidylinositol 4,5-bisphosphate implicated in synaptic vesicle recycling. Like other proteins with a role in endocytosis, synaptojanin 1 undergoes constitutive phosphorylation in resting synapses and stimulation-dependent dephosphorylation by calcineurin. Here, we show that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptojanin 1 and regulates its function ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID