RAD51
Gene Ontology Biological Process
- double-strand break repair via homologous recombination [ISS]
- homologous recombination-dependent replication fork processing [IMP]
- mating type switching [IGI]
- meiotic DNA double-strand break formation [TAS]
- meiotic DNA repair synthesis [IMP]
- meiotic gene conversion [IDA]
- mitotic recombination [IGI]
- strand invasion [IDA]
- telomere maintenance [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EXO1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Initiation of DNA damage responses through XPG-related nucleases.
Lesion-specific enzymes repair different forms of DNA damage, yet all lesions elicit the same checkpoint response. The common intermediate required to mount a checkpoint response is thought to be single-stranded DNA (ssDNA), coated by replication protein A (RPA) and containing a primer-template junction. To identify factors important for initiating the checkpoint response, we screened for genes that, when overexpressed, could ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: mitotic recombination (APO:0000225)
Additional Notes
- double mutants show decreased recombination compared to a rad51 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAD51 EXO1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.8197 | BioGRID | 524587 | |
| RAD51 EXO1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2335016 | |
| EXO1 RAD51 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 2454586 |
Curated By
- BioGRID