BAIT

MPH1

SPBC1271.16c, SPBC243.01, SPBC106.01
dual specificity protein kinase Mph1
Schizosaccharomyces pombe (972h)
PREY

NDA3

alp12, ben1, SPBC26H8.07c
tubulin beta Nda3
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe.

He X, Jones MH, Winey M, Sazer S

The spindle assembly checkpoint pathway is not essential for normal mitosis but ensures accurate nuclear division by blocking the metaphase to anaphase transition in response to a defective spindle. Here, we report the isolation of a new spindle checkpoint gene, mph1 (Mps1p-like pombe homolog), in the fission yeast Schizosaccharomyces pombe, that is required for checkpoint activation in response to spindle ... [more]

J. Cell. Sci. Jun. 01, 1998; 111(0);1635-47 [Pubmed: 9601094]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • double mutants show a loss of viabiltiy

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NDA3 MPH1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-PomBase
-

Curated By

  • BioGRID