A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Mph1, a member of the Mps1-like family of dual specificity protein kinases, is required for the spindle checkpoint in S. pombe.

He X, Jones MH, Winey M, Sazer S

The spindle assembly checkpoint pathway is not essential for normal mitosis but ensures accurate nuclear division by blocking the metaphase to anaphase transition in response to a defective spindle. Here, we report the isolation of a new spindle checkpoint gene, mph1 (Mps1p-like pombe homolog), in the fission yeast Schizosaccharomyces pombe, that is required for checkpoint activation in response to spindle ... [more]

J. Cell. Sci. Jun. 01, 1998; 111(0);1635-47 [Pubmed: 9601094]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Additional Notes

double mutants show a loss of viabiltiy

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
NDA3 MPH1	Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.	Zich J (2012)	Low	-	PomBase	-

Curated By

BioGRID

Interaction Summary

MPH1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein serine/threonine kinase activity [IDA]

Gene Ontology Cellular Component

NDA3