GCDH
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NOS3
Gene Ontology Biological Process
- arginine catabolic process [IDA]
- blood coagulation [TAS]
- blood vessel remodeling [ISS]
- endothelial cell migration [IMP]
- interaction with host [TAS]
- mitochondrion organization [ISS]
- negative regulation of blood pressure [IBA]
- negative regulation of cell proliferation [ISS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISS]
- negative regulation of muscle hyperplasia [ISS]
- negative regulation of platelet activation [NAS]
- nitric oxide biosynthetic process [IDA]
- nitric oxide mediated signal transduction [IBA]
- nitric oxide metabolic process [TAS]
- phagosome maturation [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of guanylate cyclase activity [IMP, ISS]
- positive regulation of vasodilation [NAS]
- regulation of blood pressure [NAS]
- regulation of blood vessel size [ISS, NAS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of systemic arterial blood pressure by endothelin [IMP]
- response to fluid shear stress [IEP]
- response to heat [NAS]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [ISS]
Gene Ontology Molecular Function- FMN binding [NAS]
- NADP binding [NAS]
- NADPH-hemoprotein reductase activity [IBA]
- actin monomer binding [IPI]
- arginine binding [IDA]
- cadmium ion binding [NAS]
- flavin adenine dinucleotide binding [NAS]
- heme binding [IDA]
- nitric-oxide synthase activity [IDA]
- protein binding [IPI]
- tetrahydrobiopterin binding [IDA]
- FMN binding [NAS]
- NADP binding [NAS]
- NADPH-hemoprotein reductase activity [IBA]
- actin monomer binding [IPI]
- arginine binding [IDA]
- cadmium ion binding [NAS]
- flavin adenine dinucleotide binding [NAS]
- heme binding [IDA]
- nitric-oxide synthase activity [IDA]
- protein binding [IPI]
- tetrahydrobiopterin binding [IDA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Recent advances toward the characterization of Alzheimer's disease (AD) have permitted the identification of a dozen of genetic risk factors, although many more remain undiscovered. In parallel, works in the field of network biology have shown a strong link between protein connectivity and disease. In this manuscript, we demonstrate that AD-related genes are indeed highly interconnected and, based on this ... [more]
Throughput
- Low Throughput
Ontology Terms
- sh-sy5y cell (BTO:0000793) [neuroblastoma (DOID:769)]
Related interactions
Curated By
- BioGRID