TCF3
Gene Ontology Biological Process
- B cell lineage commitment [ISO]
- Peyer's patch development [IGI]
- T cell differentiation in thymus [IMP]
- cell development [IGI]
- gastrulation [IGI]
- histone H3 acetylation [IMP]
- histone H4 acetylation [IMP]
- immunoglobulin V(D)J recombination [IMP, ISO]
- lymphocyte differentiation [IMP]
- natural killer cell differentiation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of B cell proliferation [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of gene expression [IMP, ISO]
- positive regulation of neuron differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, IGI, ISO]
- protein stabilization [IDA]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA, IGI, TAS]
- response to drug [IMP]
- response to lipopolysaccharide [IMP]
- transcription from RNA polymerase II promoter [IMP]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA, ISO]
- PDZ domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, ISO]
- protein homodimerization activity [IDA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, IGI, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- vitamin D response element binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [IDA, ISO]
- PDZ domain binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, IMP, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IMP]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA, IPI, ISO]
- protein homodimerization activity [IDA, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, IGI, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, TAS]
- transcription coactivator activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- vitamin D response element binding [ISO]
Gene Ontology Cellular Component
ASCL3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.
The salivary system in mammals is comprised of three independently developed pairs of organs, the parotid, submaxillar, and sublingual glands. Each gland is composed of various ductal and acinar cell types that fulfill multiple roles. However, the molecular mechanisms regulating their biogenesis and functions are still largely unknown. In this paper, we report that two class B basic helix-loop-helix (bHLH) ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TCF3 ASCL3 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | 737470 | |
| TCF3 ASCL3 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID