BAIT
TCF4
5730422P05Rik, ASP-I2, E2-2, E2.2, ITF-2, ITF-2b, ITF2, ME2, MITF-2A, MITF-2B, SEF-2, SEF2, SEF2-1, TFE, Tcf-4, bHLHb19
transcription factor 4
GO Process (8)
GO Function (15)
GO Component (2)
Gene Ontology Biological Process
- DNA-templated transcription, initiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of neuron differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein-DNA complex assembly [IDA]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- TFIIB-class binding transcription factor activity [IDA]
- TFIIB-class transcription factor binding [IDA]
- bHLH transcription factor binding [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding RNA polymerase recruiting transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription corepressor activity [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
ASCL3
Sgn1, bHLHa42
achaete-scute complex homolog 3 (Drosophila)
GO Process (3)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.
The salivary system in mammals is comprised of three independently developed pairs of organs, the parotid, submaxillar, and sublingual glands. Each gland is composed of various ductal and acinar cell types that fulfill multiple roles. However, the molecular mechanisms regulating their biogenesis and functions are still largely unknown. In this paper, we report that two class B basic helix-loop-helix (bHLH) ... [more]
Dev. Biol. Dec. 15, 2001; 240(2);517-30 [Pubmed: 11784080]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID