SOX8
Gene Ontology Biological Process
- Sertoli cell development [IGI]
- adipose tissue development [IMP]
- astrocyte fate commitment [IGI]
- cell fate commitment [IGI]
- cell maturation [IGI, IMP]
- enteric nervous system development [IMP]
- fat cell differentiation [IMP]
- in utero embryonic development [IGI]
- male gonad development [IGI]
- metanephric nephron tubule formation [IGI]
- morphogenesis of a branching epithelium [IGI]
- negative regulation of apoptotic process [IMP]
- negative regulation of myoblast differentiation [IDA]
- negative regulation of photoreceptor cell differentiation [IGI]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- neural crest cell migration [IMP]
- oligodendrocyte differentiation [IMP]
- osteoblast differentiation [IMP]
- peripheral nervous system development [IGI]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of gene expression [IGI]
- positive regulation of gliogenesis [IMP]
- positive regulation of kidney development [IGI]
- positive regulation of osteoblast proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- regulation of hormone levels [IMP]
- renal vesicle induction [IMP]
- retina development in camera-type eye [IGI]
- retinal rod cell differentiation [IGI]
- signal transduction [IMP]
- skeletal muscle cell differentiation [IMP]
- spermatogenesis [IGI, IMP]
- transcription from RNA polymerase II promoter [IDA]
- ureter morphogenesis [IGI]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- transcription factor binding [IPI]
- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, IMP]
- transcription factor binding [IPI]
EGR2
Gene Ontology Biological Process
- Schwann cell differentiation [IMP]
- brain segmentation [IMP]
- cellular response to cAMP [IBA]
- cellular response to gonadotropin stimulus [IBA]
- cellular response to organic substance [IDA]
- facial nerve structural organization [IGI]
- fat cell differentiation [IMP]
- motor neuron axon guidance [IGI]
- myelination [IMP]
- negative regulation of apoptotic process [IBA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein export from nucleus [IDA]
- regulation of neuronal synaptic plasticity [IBA]
- regulation of ossification [IMP]
- regulation of transcription, DNA-templated [IMP]
- response to insulin [ISO]
- rhombomere 3 development [IGI]
- rhombomere 3 formation [IMP]
- rhombomere 5 formation [IMP]
- rhythmic behavior [IDA, IMP]
- skeletal muscle cell differentiation [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA]
- HMG box domain binding [ISO]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- chromatin binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA, IMP, ISO]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors.
Sox proteins are widely believed to team up with other transcription factors as partner proteins to perform their many essential functions during development. In this study, yeast two-hybrid screens identified transcription factors as a major group of interacting proteins for Sox8 and Sox10. Interacting transcription factors were very similar for these two group E Sox proteins and included proteins with ... [more]
Throughput
- High Throughput
Additional Notes
- figure 3.
Curated By
- BioGRID