BAIT
RHP6
sng1, ubc2, SPAC18B11.07c
Rad6 homolog, ubiquitin conjugating enzyme E2 Rhp6
GO Process (10)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- cellular response to hyperoxia [IMP]
- chromatin assembly [IMP]
- chromatin remodeling [IMP]
- chromatin silencing [IMP]
- chromatin silencing at silent mating-type cassette [IGI]
- histone H2B conserved C-terminal lysine ubiquitination [IDA, IMP]
- negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels [IDA]
- negative regulation of transcription by transcription factor catabolism [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- regulation of histone H3-K4 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
CDC25
sal2, SPAC24H6.05
M phase inducer tyrosine phosphatase Cdc25
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- mitotic DNA replication checkpoint [IMP]
- peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell size [NAS]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Caffeine-mediated override of checkpoint controls. A requirement for rhp6 (Schizosaccharomyces pombe).
Cells exposed to inhibitors of DNA synthesis or suffering DNA damage are arrested or delayed in interphase through the action of checkpoint controls. If the arrested cell is exposed to caffeine, relatively normal cell cycle progression is resumed and, as observed in checkpoint control mutants, loss of checkpoint control activity is associated with a reduction in cell viability. To address ... [more]
Genetics May. 01, 1999; 152(1);61-71 [Pubmed: 10224243]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID