PPB1
Gene Ontology Biological Process
- calcium-mediated signaling [IMP]
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- cytosolic calcium ion homeostasis [IMP]
- fungal-type cell wall organization or biogenesis [IGI]
- negative regulation of calcium ion transport into cytosol [IMP]
- protein dephosphorylation [IC]
- regulation of conjugation with cellular fusion [IMP]
- regulation of establishment or maintenance of cell polarity regulating cell shape [IMP]
- regulation of mitotic cytokinesis [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PMP1
Gene Ontology Biological Process
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- inactivation of MAPK activity [IDA]
- peptidyl-tyrosine dephosphorylation [IDA]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IDA]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein dephosphorylation [IDA]
- regulation of cell morphogenesis [IMP]
- regulation of mitotic cytokinesis [IMP]
- regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
pmp1+, a suppressor of calcineurin deficiency, encodes a novel MAP kinase phosphatase in fission yeast.
Calcineurin is a highly conserved and ubiquitously expressed Ca2+- and calmodulin-dependent protein phosphatase. The in vivo role of calcineurin, however, is not fully understood. Here, we show that disruption of the calcineurin gene (ppb1(+)) in fission yeast results in a drastic chloride ion (Cl-)-sensitive growth defect and that a high copy number of a novel gene pmp1(+) suppresses this defect. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- pmp1 rescues the Cl sensitivity of a ppb1 mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPB1 PMP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 246279 | |
| PPB1 PMP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 247930 | |
| PMP1 PPB1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 737556 | |
| PPB1 PMP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 246668 | |
| PPB1 PMP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 246667 | |
| PPB1 PMP1 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 300244 | |
| PMP1 PPB1 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 737557 |
Curated By
- BioGRID