CCND3
Gene Ontology Biological Process
- T cell proliferation [IMP]
- hyaluronan biosynthetic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [IDA]
- regulation of cell cycle [IDA]
- response to peptide hormone [ISO]
- signal transduction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AURKA
Gene Ontology Biological Process
- anterior/posterior axis specification [IMP]
- centrosome localization [IMP]
- centrosome organization [IGI]
- histone-serine phosphorylation [IMP]
- meiotic nuclear division [IMP]
- meiotic spindle organization [IMP]
- microtubule cytoskeleton organization [IGI]
- mitotic cell cycle [IMP]
- mitotic centrosome separation [IGI, IMP]
- mitotic nuclear division [IMP]
- mitotic spindle organization [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein binding [ISO]
- negative regulation of spindle checkpoint [IMP]
- neuron projection extension [IGI]
- positive regulation of oocyte maturation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- protein localization to centrosome [IMP]
- protein phosphorylation [IBA, IGI, ISO]
- regulation of cytokinesis [IBA]
- regulation of protein stability [ISO]
- spindle assembly involved in female meiosis I [IMP]
- spindle stabilization [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon hillock [IDA]
- centrosome [IDA, ISO]
- chromosome passenger complex [IBA]
- condensed nuclear chromosome, centromeric region [IBA]
- germinal vesicle [IDA]
- meiotic spindle [IDA]
- microtubule cytoskeleton [ISO]
- microtubule organizing center [IGI]
- mitotic spindle [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- pronucleus [IDA]
- spindle [ISO]
- spindle microtubule [IBA, ISO]
- spindle midzone [IBA]
- spindle pole centrosome [IBA, ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
Mitotic progression is regulated by ubiquitin E3 ligase complexes to carefully orchestrate eukaryotic cell division. Here, we show that a relatively new E3 ligase component belonging to the SCF (Skip-Cullin1-F-box protein) E3 ligase family, SCF (FBXL2) , impairs cell proliferation by mediating cyclin D3 polyubiquitination and degradation. Both cyclin D3 and FBXL2 colocalize within the centrosome. FBXL2 overexpression led to ... [more]
Throughput
- Low Throughput
Additional Notes
- FBXL2 disrupts the interaction between cyclin D3 and CDK11 and association with PLK4 and Aurora A
Curated By
- BioGRID