CHRNA7
Gene Ontology Biological Process
- B cell activation [IMP]
- T cell activation [IMP]
- activation of MAPK activity [ISO]
- associative learning [IGI, IMP]
- behavioral response to ethanol [IMP]
- behavioral response to nicotine [IGI]
- calcium ion transport [ISO]
- cation transmembrane transport [IMP, ISO]
- cellular calcium ion homeostasis [ISO]
- cognition [ISO]
- endocytosis [IMP]
- generation of ovulation cycle rhythm [IMP]
- ion transmembrane transport [ISO]
- ion transport [IMP]
- memory [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-1 beta production [IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of tumor necrosis factor production [IMP, ISO]
- neuronal action potential [ISO]
- ovulation cycle [IMP]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure [IMP]
- regulation of inflammatory response [IMP]
- regulation of membrane potential [IMP, ISO]
- regulation of norepinephrine secretion [IMP]
- regulation of synaptic transmission, dopaminergic [IMP]
- response to ethanol [IMP]
- response to food [IMP]
- response to hypoxia [ISO]
- response to nicotine [IMP, ISO]
- signal transduction [ISO]
- sperm motility [IMP]
- synaptic transmission, cholinergic [IMP, ISO]
Gene Ontology Molecular Function- ATPase binding [ISO]
- acetylcholine binding [ISO]
- acetylcholine receptor activity [ISO]
- acetylcholine-activated cation-selective channel activity [IDA, IMP, ISO]
- acetylcholine-gated cation channel activity [ISO]
- adenylate cyclase binding [ISO]
- beta-amyloid binding [ISO]
- chloride channel regulator activity [ISO]
- drug binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- scaffold protein binding [ISO]
- toxic substance binding [ISO]
- ATPase binding [ISO]
- acetylcholine binding [ISO]
- acetylcholine receptor activity [ISO]
- acetylcholine-activated cation-selective channel activity [IDA, IMP, ISO]
- acetylcholine-gated cation channel activity [ISO]
- adenylate cyclase binding [ISO]
- beta-amyloid binding [ISO]
- chloride channel regulator activity [ISO]
- drug binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- scaffold protein binding [ISO]
- toxic substance binding [ISO]
Gene Ontology Cellular Component
- acetylcholine-gated channel complex [ISO]
- apical plasma membrane [IDA]
- asymmetric synapse [ISO]
- axon [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendritic shaft [ISO]
- dendritic spine [ISO]
- external side of plasma membrane [IDA]
- growth cone [ISO]
- membrane [IDA]
- membrane raft [ISO]
- neuronal cell body [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
- presynaptic membrane [ISO]
LYNX1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Novel modulation of neuronal nicotinic acetylcholine receptors by association with the endogenous prototoxin lynx1.
We previously identified lynx1 as a neuronal membrane molecule related to snake alpha-neurotoxins able to modulate nAChRs. Here, we show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs. Single-channel recordings show that lynx1 promotes the largest of three current amplitudes elicited by ACh through alpha(4)beta(2) nAChRs and that lynx1 enhances desensitization. Macroscopic recordings quantify the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID