HTT
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- Golgi organization [ISO]
- L-glutamate import [IMP]
- anatomical structure morphogenesis [IMP]
- anterior/posterior pattern specification [IMP]
- apoptotic process [IMP]
- associative learning [IMP]
- axon cargo transport [IMP]
- brain development [IMP]
- cell aging [IMP]
- central nervous system development [IMP]
- citrulline metabolic process [IMP]
- determination of adult lifespan [IMP]
- dopamine receptor signaling pathway [IMP]
- embryo development [IMP]
- endoplasmic reticulum organization [IMP]
- endosomal transport [IMP]
- establishment of mitotic spindle orientation [ISO]
- gastrulation [IMP]
- grooming behavior [IMP]
- hormone metabolic process [IMP]
- insulin secretion [IMP]
- iron ion homeostasis [IMP]
- lactate biosynthetic process from pyruvate [IMP]
- learning [IMP]
- learning or memory [IMP]
- locomotory behavior [IMP]
- mRNA transport [ISO]
- mitochondrial transport [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cysteine-type endopeptidase activity [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron death [IMP]
- neural plate formation [IMP]
- neurogenesis [IMP]
- neuron apoptotic process [IMP]
- neuron development [IMP]
- olfactory lobe development [IMP]
- paraxial mesoderm formation [IMP]
- peptide hormone secretion [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- protein import into nucleus [IMP]
- quinolinate biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of protein phosphatase type 2A activity [ISO]
- regulation of synaptic plasticity [IMP]
- response to calcium ion [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [ISO]
- social behavior [IMP]
- spermatogenesis [IMP]
- striatum development [IMP]
- urea cycle [IMP]
- vesicle transport along microtubule [IDA, ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- autophagic vacuole [ISO]
- axon [IDA, ISO]
- cell [IMP]
- clathrin-coated vesicle [ISO]
- cytoplasm [IDA, IMP, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic vesicle membrane [ISO]
- cytosol [ISO]
- dendrite [ISO]
- endoplasmic reticulum [ISO]
- inclusion body [IDA]
- intracellular [IMP]
- late endosome [ISO]
- mitochondrion [IMP]
- neuronal cell body [ISO]
- neuronal ribonucleoprotein granule [ISO]
- nucleoplasm [ISO]
- nucleus [IBA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
CACNA2D1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involving mutant Htt. We therefore hypothesized that genetic modifiers of HD neurodegeneration should be enriched among Htt protein interactors. To test this idea, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HTT CACNA2D1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID