BAIT

DIRAS1

Di-Ras1, GBTS1, RIG
DIRAS family, GTP-binding RAS-like 1
GO Process (2)
GO Function (3)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens
PREY

APP

AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
amyloid beta (A4) precursor protein
GO Process (29)
GO Function (8)
GO Component (21)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.

Olah J, Vincze O, Virok D, Simon D, Bozso Z, Tokesi N, Horvath I, Hlavanda E, Kovacs J, Magyar A, Szucs M, Orosz F, Penke B, Ovadi J

The disordered tubulin polymerization promoting protein (TPPP/p25) was found to be co-enriched in neuronal and glial inclusions with α-synuclein in Parkinson disease and multiple system atrophy, respectively; however, co-occurrence of α-synuclein with β-amyloid (Aβ) in human brain inclusions has been recently reported, suggesting the existence of mixed type pathologies that could result in obstacles in the correct diagnosis and treatment. ... [more]

J. Biol. Chem. Sep. 30, 2011; 286(39);34088-100 [Pubmed: 21832049]

Throughput

  • High Throughput

Curated By

  • BioGRID