BAIT
A2M
A2MD, CPAMD5, FWP007, S863-7
alpha-2-macroglobulin
GO Process (10)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NOS3
ECNOS, eNOS
nitric oxide synthase 3 (endothelial cell)
GO Process (26)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- arginine catabolic process [IDA]
- blood coagulation [TAS]
- blood vessel remodeling [ISS]
- endothelial cell migration [IMP]
- interaction with host [TAS]
- mitochondrion organization [ISS]
- negative regulation of blood pressure [IBA]
- negative regulation of cell proliferation [ISS]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISS]
- negative regulation of muscle hyperplasia [ISS]
- negative regulation of platelet activation [NAS]
- nitric oxide biosynthetic process [IDA]
- nitric oxide mediated signal transduction [IBA]
- nitric oxide metabolic process [TAS]
- phagosome maturation [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of guanylate cyclase activity [IMP, ISS]
- positive regulation of vasodilation [NAS]
- regulation of blood pressure [NAS]
- regulation of blood vessel size [ISS, NAS]
- regulation of nitric-oxide synthase activity [TAS]
- regulation of systemic arterial blood pressure by endothelin [IMP]
- response to fluid shear stress [IEP]
- response to heat [NAS]
- small molecule metabolic process [TAS]
- smooth muscle hyperplasia [ISS]
Gene Ontology Molecular Function- FMN binding [NAS]
- NADP binding [NAS]
- NADPH-hemoprotein reductase activity [IBA]
- actin monomer binding [IPI]
- arginine binding [IDA]
- cadmium ion binding [NAS]
- flavin adenine dinucleotide binding [NAS]
- heme binding [IDA]
- nitric-oxide synthase activity [IDA]
- protein binding [IPI]
- tetrahydrobiopterin binding [IDA]
- FMN binding [NAS]
- NADP binding [NAS]
- NADPH-hemoprotein reductase activity [IBA]
- actin monomer binding [IPI]
- arginine binding [IDA]
- cadmium ion binding [NAS]
- flavin adenine dinucleotide binding [NAS]
- heme binding [IDA]
- nitric-oxide synthase activity [IDA]
- protein binding [IPI]
- tetrahydrobiopterin binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Recent advances toward the characterization of Alzheimer's disease (AD) have permitted the identification of a dozen of genetic risk factors, although many more remain undiscovered. In parallel, works in the field of network biology have shown a strong link between protein connectivity and disease. In this manuscript, we demonstrate that AD-related genes are indeed highly interconnected and, based on this ... [more]
Genome Res. Mar. 01, 2011; 21(3);364-76 [Pubmed: 21163940]
Throughput
- Low Throughput
Curated By
- BioGRID