BAIT
A2M
A2MD, CPAMD5, FWP007, S863-7
alpha-2-macroglobulin
GO Process (10)
GO Function (10)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood coagulation, intrinsic pathway [TAS]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- negative regulation of complement activation, lectin pathway [IDA]
- negative regulation of endopeptidase activity [IDA]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TYRO3
BYK, Dtk, Etk-2, RSE, Rek, Sky, Tif
TYRO3 protein tyrosine kinase
GO Process (20)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- apoptotic cell clearance [ISS]
- cell adhesion [NAS]
- forebrain cell migration [ISS]
- negative regulation of inflammatory response [ISS]
- negative regulation of innate immune response [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of toll-like receptor signaling pathway [ISS]
- neuron cellular homeostasis [ISS]
- ovulation cycle [ISS]
- peptidyl-tyrosine phosphorylation [IDA, NAS]
- phosphatidylinositol 3-kinase signaling [NAS]
- platelet activation [ISS]
- platelet aggregation [ISS]
- protein autophosphorylation [IDA]
- protein kinase B signaling [ISS]
- secretion by cell [ISS]
- signal transduction [NAS]
- signal transduction by phosphorylation [NAS]
- spermatogenesis [ISS]
- substrate adhesion-dependent cell spreading [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Recent advances toward the characterization of Alzheimer's disease (AD) have permitted the identification of a dozen of genetic risk factors, although many more remain undiscovered. In parallel, works in the field of network biology have shown a strong link between protein connectivity and disease. In this manuscript, we demonstrate that AD-related genes are indeed highly interconnected and, based on this ... [more]
Genome Res. Mar. 01, 2011; 21(3);364-76 [Pubmed: 21163940]
Throughput
- Low Throughput
Curated By
- BioGRID