CACNA1B
Gene Ontology Biological Process
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IBA, IMP]
- calcium ion transport [IMP, ISO]
- locomotory behavior [IMP]
- membrane depolarization during action potential [IBA]
- neurotransmitter secretion [IMP]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of blood pressure [IMP]
- regulation of calcium ion transport [IMP]
- regulation of heart contraction [IMP]
- regulation of ion transmembrane transport [IMP]
- response to organic cyclic compound [ISO]
- response to pain [IMP]
- response to testosterone [ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CACNB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain.
Neuronal voltage-dependent Ca2+ channels are heteromultimers of alpha1, beta, and alpha2delta subunits, and any one of five alpha1 subunits (alpha1A-E) may associate with one of four beta subunits (beta1-4). The specific alpha1-beta combination assembled determines single-channel properties, while variation in the proportion of each combination contributes to the functional diversity of neurons. The mouse mutant lethargic (lh) exhibits severe neurological ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID