CSK
Gene Ontology Biological Process
- adherens junction organization [IBA]
- cell differentiation [IBA]
- cell migration [IBA]
- cellular response to peptide hormone stimulus [ISO]
- central nervous system development [IBA]
- innate immune response [IBA]
- intracellular signal transduction [TAS]
- morphogenesis of an epithelium [IBA]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of Golgi to plasma membrane protein transport [ISO]
- negative regulation of bone resorption [ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of kinase activity [ISO]
- negative regulation of low-density lipoprotein particle clearance [ISO]
- negative regulation of phagocytosis [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of MAP kinase activity [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO, TAS]
- regulation of Fc receptor mediated stimulatory signaling pathway [IBA, ISO]
- regulation of T cell activation [TAS]
- regulation of cytokine production [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CDH5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Association of Csk to VE-cadherin and inhibition of cell proliferation.
Vascular endothelial cadherin (VE-cadherin) mediates contact inhibition of cell growth in quiescent endothelial cell layers. Searching for proteins that could be involved in VE-cadherin signaling, we found the cytosolic C-terminal Src kinase (Csk), a negative regulator of Src family kinases. We show that Csk binds via its SH2 domain to the phosphorylated tyrosine 685 of VE-cadherin. VE-cadherin recruits Csk to ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDH5 CSK | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID