CRY2
Gene Ontology Biological Process
- circadian regulation of gene expression [IGI, IMP]
- circadian rhythm [IMP]
- entrainment of circadian clock by photoperiod [IMP]
- glucose homeostasis [IGI]
- lipid storage [IGI]
- negative regulation of circadian rhythm [IDA]
- negative regulation of glucocorticoid receptor signaling pathway [IGI]
- negative regulation of glucocorticoid secretion [IGI]
- negative regulation of phosphoprotein phosphatase activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IGI, ISO]
- protein import into nucleus [IPI]
- regulation of circadian rhythm [IMP]
- response to insulin [IGI]
Gene Ontology Molecular Function- DNA binding [ISO]
- FAD binding [IDA]
- damaged DNA binding [ISO]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- single-stranded DNA binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin binding [ISO]
- DNA binding [ISO]
- FAD binding [IDA]
- damaged DNA binding [ISO]
- kinase binding [IPI]
- nuclear hormone receptor binding [IPI]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- single-stranded DNA binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- transcription regulatory region sequence-specific DNA binding [IDA]
- ubiquitin binding [ISO]
PER3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal.
Circadian rhythms, which period is approximately one day, are generated by endogenous biological clocks. These clocks are found throughout the animal kingdom, as well as in plants and even in prokaryotes. Molecular mechanisms for circadian rhythms are based on transcriptional oscillation of clock component genes, consisting of interwoven autoregulatory feedback loops. Among the loops, the nuclear transport of clock proteins ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CRY2 PER3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID