MCL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DNA2
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO]
- DNA catabolic process, exonucleolytic [IDA]
- DNA duplex unwinding [ISO]
- DNA repair [ISS]
- removal of RNA primer involved in mitotic DNA replication [IMP]
- replication fork processing [IMP]
- replication fork reversal [IMP]
- response to intra-S DNA damage checkpoint signaling [IMP]
- telomere maintenance [IGI]
- telomeric 3' overhang formation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
mcl1+, the Schizosaccharomyces pombe homologue of CTF4, is important for chromosome replication, cohesion, and segregation.
The fission yeast minichromosome loss mutant mcl1-1 was identified in a screen for mutants defective in chromosome segregation. Missegregation of the chromosomes in mcl1-1 mutant cells results from decreased centromeric cohesion between sister chromatids. mcl1+ encodes a beta-transducin-like protein with similarity to a family of eukaryotic proteins that includes Ctf4p from Saccharomyces cerevisiae, sepB from Aspergillus nidulans, and AND-1 from ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MCL1 DNA2 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | Low | - | BioGRID | 248187 |
Curated By
- BioGRID