BAIT
PRDX5
ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, prx-V, SBBI10
peroxiredoxin 5
GO Process (12)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- NADPH oxidation [IDA]
- cellular response to reactive oxygen species [IMP]
- hydrogen peroxide catabolic process [IDA]
- inflammatory response [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of oxidoreductase activity [IDA]
- negative regulation of transcription from RNA polymerase III promoter [IDA]
- positive regulation of collagen biosynthetic process [IDA]
- reactive nitrogen species metabolic process [IDA]
- regulation of apoptosis involved in tissue homeostasis [IDA]
- response to oxidative stress [IDA]
Gene Ontology Molecular Function- RNA polymerase III regulatory region DNA binding [IDA]
- antioxidant activity [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- peroxidase activity [IDA]
- peroxiredoxin activity [IDA]
- peroxynitrite reductase activity [IDA]
- protein dimerization activity [IDA]
- receptor binding [IPI]
- RNA polymerase III regulatory region DNA binding [IDA]
- antioxidant activity [IDA]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- peroxidase activity [IDA]
- peroxiredoxin activity [IDA]
- peroxynitrite reductase activity [IDA]
- protein dimerization activity [IDA]
- receptor binding [IPI]
Gene Ontology Cellular Component
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [IDA, TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- intracellular membrane-bounded organelle [IDA]
- mitochondrial matrix [TAS]
- mitochondrion [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- peroxisomal matrix [IDA]
- peroxisome [IDA]
Homo sapiens
PREY
SOD1
ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer
superoxide dismutase 1, soluble
GO Process (50)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- activation of MAPK activity [ISS]
- anterograde axon cargo transport [ISS]
- auditory receptor cell stereocilium organization [ISS]
- blood coagulation [TAS]
- cell aging [IMP]
- cellular iron ion homeostasis [ISS]
- embryo implantation [ISS, NAS]
- glutathione metabolic process [ISS]
- heart contraction [IDA]
- hydrogen peroxide biosynthetic process [IDA, ISS]
- locomotory behavior [ISS]
- muscle cell cellular homeostasis [ISS]
- myeloid cell homeostasis [ISS]
- negative regulation of cholesterol biosynthetic process [IDA]
- negative regulation of neuron apoptotic process [ISS]
- neurofilament cytoskeleton organization [ISS]
- ovarian follicle development [ISS]
- peripheral nervous system myelin maintenance [ISS]
- placenta development [NAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [IC]
- positive regulation of catalytic activity [IDA]
- positive regulation of cytokine production [IDA]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]
- positive regulation of superoxide anion generation [IDA]
- reactive oxygen species metabolic process [IDA]
- regulation of Rac GTPase activity [IDA]
- regulation of T cell differentiation in thymus [NAS]
- regulation of blood pressure [ISS]
- regulation of mitochondrial membrane potential [IMP]
- regulation of multicellular organism growth [ISS]
- regulation of organ growth [NAS]
- regulation of protein kinase activity [IDA]
- relaxation of vascular smooth muscle [ISS]
- removal of superoxide radicals [IBA, IC, ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to ethanol [ISS]
- response to heat [ISS]
- response to hydrogen peroxide [ISS]
- response to organic substance [IDA]
- response to superoxide [IDA]
- retina homeostasis [ISS]
- retrograde axon cargo transport [ISS]
- sensory perception of sound [ISS]
- spermatogenesis [ISS]
- superoxide metabolic process [IDA, ISS]
- thymus development [NAS]
- transmission of nerve impulse [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [IDA, TAS]
- dendrite cytoplasm [IDA]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- mitochondrial intermembrane space [TAS]
- mitochondrial matrix [NAS]
- mitochondrion [IDA]
- neuronal cell body [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
- peroxisome [IDA, ISS]
- plasma membrane [IDA]
- protein complex [IDA]
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A census of human soluble protein complexes.
Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, ... [more]
Cell Aug. 31, 2012; 150(5);1068-81 [Pubmed: 22939629]
Quantitative Score
- 0.97 [Denoised score]
Throughput
- High Throughput
Additional Notes
- Denoised score >= 0.75
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SOD1 PRDX5 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.0011 | BioGRID | 2362395 | |
| SOD1 PRDX5 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.6975 | BioGRID | 1267355 |
Curated By
- BioGRID