BAIT
HGS
HRS
hepatocyte growth factor-regulated tyrosine kinase substrate
GO Process (13)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RANGRF
HSPC236, MOG1, RANGNRF, HSPC165
RAN guanine nucleotide release factor
GO Process (11)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- ER to Golgi vesicle-mediated transport [IMP]
- positive regulation of GTPase activity [ISS]
- positive regulation of establishment of protein localization to plasma membrane [IMP]
- positive regulation of protein localization to cell surface [IDA, IMP]
- protein exit from endoplasmic reticulum [IMP]
- regulation of heart rate [TAS]
- regulation of membrane depolarization [IDA, IMP]
- regulation of membrane depolarization during cardiac muscle cell action potential [TAS]
- regulation of membrane potential [IDA]
- regulation of sodium ion transmembrane transport [IDA, IMP]
- regulation of sodium ion transmembrane transporter activity [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
A census of human soluble protein complexes.
Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, ... [more]
Cell Aug. 31, 2012; 150(5);1068-81 [Pubmed: 22939629]
Quantitative Score
- 0.793 [Denoised score]
Throughput
- High Throughput
Additional Notes
- Denoised score >= 0.75
Curated By
- BioGRID