BAIT

EEF2

EEF-2, EF-2, EF2, SCA26

eukaryotic translation elongation factor 2

GO Process (6)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

gene expression [TAS]

positive regulation of gene expression [IGI]

positive regulation of translation [IGI]

translation [TAS]

translational elongation [TAS]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]
translation activator activity [IGI]

Gene Ontology Cellular Component

aggresome [IDA]

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

plasma membrane [IDA]

ribonucleoprotein complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EPHA2

ARCC2, CTPA, CTPP1, CTRCT6, ECK

EPH receptor A2

Synthetic Protein Interaction Project

GO Process (23)

GO Function (2)

GO Component (5)

Gene Ontology Biological Process

activation of Rac GTPase activity [IMP]

bone remodeling [ISS]

branching involved in mammary gland duct morphogenesis [ISS]

cell chemotaxis [IMP]

cell migration [IMP]

ephrin receptor signaling pathway [IDA]

intrinsic apoptotic signaling pathway in response to DNA damage [IDA]

keratinocyte differentiation [IMP]

lens fiber cell morphogenesis [ISS]

mammary gland epithelial cell proliferation [ISS]

multicellular organismal development [TAS]

negative regulation of protein kinase B signaling [IDA]

osteoblast differentiation [ISS]

osteoclast differentiation [ISS]

peptidyl-tyrosine phosphorylation [IDA]

positive regulation of establishment of protein localization to plasma membrane [IMP]

protein kinase B signaling [IDA]

regulation of ERK1 and ERK2 cascade [IMP]

regulation of angiogenesis [ISS]

regulation of blood vessel endothelial cell migration [ISS]

regulation of cell adhesion mediated by integrin [IDA]

regulation of lamellipodium assembly [IMP]

response to growth factor [IMP]

Gene Ontology Molecular Function

protein binding [IPI]
transmembrane receptor protein tyrosine kinase activity [IDA]

Gene Ontology Cellular Component

cell surface [IDA]

focal adhesion [IDA]

integral component of plasma membrane [IDA]

leading edge membrane [IDA]

plasma membrane [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

A census of human soluble protein complexes.

Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, Li Z, Wang PI, Boutz DR, Fong V, Phanse S, Babu M, Craig SA, Hu P, Wan C, Vlasblom J, Dar VU, Bezginov A, Clark GW, Wu GC, Wodak SJ, Tillier ER, Paccanaro A, Marcotte EM, Emili A

Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, ... [more]

Cell Aug. 31, 2012; 150(5);1068-81 [Pubmed: 22939629]

Quantitative Score

0.791 [Denoised score]

Throughput

High Throughput

Additional Notes

Denoised score >= 0.75

Curated By

BioGRID