BAIT

PNPT1

COXPD13, DFNB70, OLD35, PNPASE, old-35

polyribonucleotide nucleotidyltransferase 1

GO Process (24)

GO Function (7)

GO Component (4)

Gene Ontology Biological Process

RNA catabolic process [IDA]

RNA import into mitochondrion [IDA]

RNA phosphodiester bond hydrolysis, exonucleolytic [IDA]

RNA polyadenylation [IDA]

cellular response to interferon-beta [IDA]

cellular response to oxidative stress [IDA]

mRNA catabolic process [IDA]

mitochondrial RNA 3'-end processing [IMP]

mitochondrial RNA 5'-end processing [IMP]

mitochondrial RNA catabolic process [IDA]

mitochondrial mRNA catabolic process [IDA]

mitochondrial mRNA polyadenylation [IMP]

mitochondrion morphogenesis [ISS]

mitotic cell cycle arrest [IDA]

negative regulation of growth [IDA]

nuclear polyadenylation-dependent mRNA catabolic process [IDA]

positive regulation of mRNA catabolic process [IMP]

positive regulation of miRNA catabolic process [IDA]

positive regulation of mitochondrial RNA catabolic process [IDA]

protein homooligomerization [IDA]

protein homotrimerization [IDA]

rRNA import into mitochondrion [IDA]

regulation of cellular respiration [ISS]

regulation of cellular senescence [IDA]

Gene Ontology Molecular Function

3'-5'-exoribonuclease activity [IDA]
miRNA binding [IDA]
poly(A) RNA binding [IDA]
poly(G) binding [IDA]
poly(U) RNA binding [IDA]
polyribonucleotide nucleotidyltransferase activity [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

mitochondrial degradosome [IDA]

mitochondrial intermembrane space [IDA]

mitochondrion [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

RANGAP1

Fug1, RANGAP, SD, RP4-756G23.7

Ran GTPase activating protein 1

GO Process (3)

GO Function (1)

GO Component (5)

Gene Ontology Biological Process

mitotic cell cycle [TAS]

negative regulation of protein export from nucleus [IDA]

positive regulation of Ran GTPase activity [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

kinetochore [IDA]

nuclear membrane [IDA]

nuclear pore [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

A census of human soluble protein complexes.

Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, Li Z, Wang PI, Boutz DR, Fong V, Phanse S, Babu M, Craig SA, Hu P, Wan C, Vlasblom J, Dar VU, Bezginov A, Clark GW, Wu GC, Wodak SJ, Tillier ER, Paccanaro A, Marcotte EM, Emili A

Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, ... [more]

Cell Aug. 31, 2012; 150(5);1068-81 [Pubmed: 22939629]

Quantitative Score

0.773 [Denoised score]

Throughput

High Throughput

Additional Notes

Denoised score >= 0.75

Curated By

BioGRID