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BAIT

VCP

ALS14, HEL-220, HEL-S-70, IBMPFD, IBMPFD1, TERA, p97

valosin containing protein

Autophagy Project

GO Process (18)

GO Function (8)

GO Component (13)

Gene Ontology Biological Process

DNA repair [NAS]

ER-associated ubiquitin-dependent protein catabolic process [IDA, IMP, TAS]

activation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]

cellular response to DNA damage stimulus [IDA]

double-strand break repair [IDA]

endoplasmic reticulum unfolded protein response [TAS]

establishment of protein localization [TAS]

positive regulation of Lys63-specific deubiquitinase activity [IDA]

positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]

positive regulation of protein K63-linked deubiquitination [IDA]

positive regulation of protein catabolic process [IDA]

positive regulation of protein complex assembly [IDA]

proteasome-mediated ubiquitin-dependent protein catabolic process [NAS]

protein N-linked glycosylation via asparagine [IMP]

protein ubiquitination [IDA, NAS]

regulation of apoptotic process [TAS]

retrograde protein transport, ER to cytosol [IDA]

translesion synthesis [IMP]

Gene Ontology Molecular Function

ATPase activity [TAS]
deubiquitinase activator activity [IDA]
poly(A) RNA binding [IDA]
polyubiquitin binding [IDA]
protein binding [IPI]
protein domain specific binding [IPI]
protein phosphatase binding [IPI]
ubiquitin-specific protease binding [IPI]

Gene Ontology Cellular Component

Hrd1p ubiquitin ligase complex [IDA]

cytoplasm [IDA]

endoplasmic reticulum [IDA]

endoplasmic reticulum membrane [IDA]

extracellular vesicular exosome [IDA]

intracellular membrane-bounded organelle [ISS]

lipid particle [IDA]

nucleoplasm [IDA]

nucleus [IDA, TAS]

perinuclear region of cytoplasm [IDA]

proteasome complex [IDA]

site of double-strand break [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

TXN2

MT-TRX, MTRX, TRX2, RP5-1119A7.13-005

thioredoxin 2

GO Process (0)

GO Function (0)

GO Component (3)

Gene Ontology Cellular Component

mitochondrial matrix [TAS]

mitochondrion [IDA]

nucleolus [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-fractionation

Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.

Publication

A census of human soluble protein complexes.

Havugimana PC, Hart GT, Nepusz T, Yang H, Turinsky AL, Li Z, Wang PI, Boutz DR, Fong V, Phanse S, Babu M, Craig SA, Hu P, Wan C, Vlasblom J, Dar VU, Bezginov A, Clark GW, Wu GC, Wodak SJ, Tillier ER, Paccanaro A, Marcotte EM, Emili A

Cellular processes often depend on stable physical associations between proteins. Despite recent progress, knowledge of the composition of human protein complexes remains limited. To close this gap, we applied an integrative global proteomic profiling approach, based on chromatographic separation of cultured human cell extracts into more than one thousand biochemical fractions that were subsequently analyzed by quantitative tandem mass spectrometry, ... [more]

Cell Aug. 31, 2012; 150(5);1068-81 [Pubmed: 22939629]

Quantitative Score

0.751 [Denoised score]

Throughput

High Throughput

Additional Notes

Denoised score >= 0.75

Curated By

BioGRID