BAIT
AGO1
csp9, SPCC736.11
argonaute
GO Process (12)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- RNA phosphodiester bond hydrolysis, endonucleolytic [IDA]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromatin silencing by small RNA [IMP]
- co-transcriptional gene silencing by RNA interference machinery [IMP]
- conversion of ds siRNA to ss siRNA involved in RNA interference [IMP]
- heterochromatin assembly involved in chromatin silencing by small RNA [IMP]
- mitotic sister chromatid segregation [IGI]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of chromatin silencing at centromere [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RPL2102
rpl21, rpl21-2, SPAC959.08
60S ribosomal protein L21 (predicted)
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Mol. Cell Jun. 08, 2012; 46(5);691-704 [Pubmed: 22681890]
Quantitative Score
- -4.082776867 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID