BAIT
HIP1
hir1, SPBC31F10.13c
hira protein, histone chaperone Hip1
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- DNA replication-independent nucleosome assembly [TAS]
- cellular response to nitrogen starvation [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
MTO1
mbo1, mod20, SPCC417.07c
MT organizer Mto1
GO Process (9)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- astral microtubule organization [IMP]
- attachment of mitotic spindle microtubules to kinetochore [IGI]
- cellular protein localization [IMP]
- dynein-driven meiotic oscillatory nuclear movement [IMP]
- establishment of nucleus localization [IMP]
- gamma-tubulin complex localization [IMP]
- interphase microtubule nucleation by interphase microtubule organizing center [IMP]
- karyogamy [IMP]
- regulation of double-strand break repair via homologous recombination [EXP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Mol. Cell Jun. 08, 2012; 46(5);691-704 [Pubmed: 22681890]
Quantitative Score
- -2.330101035 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID