BAIT
SPAC4C5.01
haloacid dehalogenase-like hydrolase
GO Process (0)
GO Function (0)
GO Component (3)
Schizosaccharomyces pombe (972h)
PREY
GIT5
gpb1, SPBC32H8.07
heterotrimeric G protein beta subunit Git5
GO Process (7)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway [TAS]
- cAMP-mediated signaling [IMP]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of conjugation with cellular fusion [IMP]
- negative regulation of transcription by glucose [IMP]
- positive regulation of protein binding [IDA]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Mol. Cell Jun. 08, 2012; 46(5);691-704 [Pubmed: 22681890]
Quantitative Score
- -2.91625244 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID