BAIT
SHK2
pak2, SPAC1F5.09c
PAK-related kinase Shk2
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
RAF1
clr8, cmc1, dos1, SPCC613.12c
CLRC ubiquitin E3 ligase complex specificiy factor Raf1/Dos1
GO Process (14)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- cellular protein localization [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IMP]
- chromatin silencing at telomere [IMP]
- chromatin silencing by small RNA [IMP]
- maintenance of chromatin silencing at silent mating-type cassette [NAS]
- meiotic chromosome segregation [IMP]
- meiotic sister chromatid cohesion, centromeric [IMP]
- meiotic telomere clustering [IMP]
- mitotic sister chromatid segregation [IMP]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K9 methylation [IMP]
- regulation of mating type switching [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Mol. Cell Jun. 08, 2012; 46(5);691-704 [Pubmed: 22681890]
Quantitative Score
- -3.816954474 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID