BAIT
PMK1
spm1, SPBC119.08
MAP kinase Pmk1
GO Process (7)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [IDA]
- MAPK cascade involved in cell wall organization or biogenesis [IDA, IMP]
- cellular sodium ion homeostasis [ISS]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of calcium ion transport into cytosol [IMP]
- positive regulation of calcium-mediated signaling [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [EXP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SPAC4A8.14
prs1
ribose-phosphate pyrophosphokinase (predicted)
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Mol. Cell Jun. 08, 2012; 46(5);691-704 [Pubmed: 22681890]
Quantitative Score
- -2.580087794 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID