SNF5
Gene Ontology Biological Process
- chromatin remodeling [ISO]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IEP]
- positive regulation of cell-substrate adhesion [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IEP]
- regulation of glucose import by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of iron ion import by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SPBC16H5.13
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Quantitative Score
- -3.211163479 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SNF5 SPBC16H5.13 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -6.1524 | BioGRID | 523933 | |
| SPBC16H5.13 SNF5 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.2112 | BioGRID | 779569 |
Curated By
- BioGRID