SIR2
Gene Ontology Biological Process
- chromatin silencing [IMP]
- chromatin silencing at centromere [IMP]
- chromatin silencing at silent mating-type cassette [IGI, IMP]
- chromatin silencing at telomere [IMP]
- histone H3 deacetylation [IDA]
- histone H3-K9 modification [IDA]
- histone H4 deacetylation [IDA]
- histone deacetylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IEP]
- positive regulation of heterochromatin assembly [EXP]
- protein localization to chromosome, telomeric region [IMP]
- regulation of histone H3-K9 methylation [IMP]
Gene Ontology Molecular Function- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase activity (H3-K14 specific) [IDA]
- histone deacetylase activity (H3-K4 specific) [IDA]
- histone deacetylase activity (H3-K9 specific) [IDA]
- histone deacetylase activity (H4-K16 specific) [IDA]
- NAD+ binding [IDA]
- NAD-dependent histone deacetylase activity (H3-K9 specific) [IDA]
- NAD-dependent histone deacetylase activity (H4-K16 specific) [IDA]
- histone deacetylase activity [IDA]
- histone deacetylase activity (H3-K14 specific) [IDA]
- histone deacetylase activity (H3-K4 specific) [IDA]
- histone deacetylase activity (H3-K9 specific) [IDA]
- histone deacetylase activity (H4-K16 specific) [IDA]
Gene Ontology Cellular Component
MCL1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Hierarchical Modularity and the Evolution of Genetic Interactomes across Species.
To date, cross-species comparisons of genetic interactomes have been restricted to small or functionally related gene sets, limiting our ability to infer evolutionary trends. To facilitate a more comprehensive analysis, we constructed a genome-scale epistasis map (E-MAP) for the fission yeast Schizosaccharomyces pombe, providing phenotypic signatures for ∼60% of the nonessential genome. Using these signatures, we generated a catalog of ... [more]
Quantitative Score
- -3.452874256 [S score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- An Epistatic MiniArray Profile (E-MAP) approach was used to quantitatively score genetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score > 1.8 for positive interactions (epistatic or suppressor interactions) and S score < -2.3 for negative interactions (synthetic sick/lethal interactions).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MCL1 SIR2 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | PomBase | - | |
| MCL1 SIR2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -3.4529 | BioGRID | 765537 |
Curated By
- BioGRID