BAIT
BAD
AI325008, Bbc2
BCL2-associated agonist of cell death
GO Process (39)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP metabolic process [IMP]
- ATP metabolic process [IMP]
- activation of cysteine-type endopeptidase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISO]
- apoptotic process [ISO]
- apoptotic signaling pathway [IDA, IMP]
- cell proliferation [IDA]
- cellular process regulating host cell cycle in response to virus [IDA]
- cellular response to nicotine [ISO]
- cellular response to organic substance [ISO]
- cytokine-mediated signaling pathway [IDA]
- extrinsic apoptotic signaling pathway [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA, IGI, IMP]
- extrinsic apoptotic signaling pathway via death domain receptors [IMP]
- glucose catabolic process [IMP]
- glucose homeostasis [IMP]
- intrinsic apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA, IMP]
- pore complex assembly [ISO]
- positive regulation of B cell differentiation [IMP]
- positive regulation of T cell differentiation [IMP]
- positive regulation of apoptotic process [IDA, ISO]
- positive regulation of apoptotic process by virus [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucokinase activity [IMP]
- positive regulation of insulin secretion [IMP]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of mitochondrial membrane potential [IMP]
- positive regulation of neuron death [ISO]
- positive regulation of proteolysis [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of type B pancreatic cell development [IMP]
- regulation of apoptotic process [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- release of cytochrome c from mitochondria [IMP]
- suppression by virus of host apoptotic process [IDA, IMP]
- type B pancreatic cell proliferation [IMP]
Gene Ontology Molecular Function- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
- cysteine-type endopeptidase activator activity involved in apoptotic process [IDA, ISO]
- lipid binding [ISO]
- phospholipid binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2B binding [ISO]
- protein phosphatase binding [IPI]
Gene Ontology Cellular Component
Mus musculus
PREY
SOD2
MnSOD, Sod-2
superoxide dismutase 2, mitochondrial
GO Process (51)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- age-dependent response to oxidative stress [IMP]
- age-dependent response to reactive oxygen species [ISO]
- apoptotic mitochondrial changes [IMP]
- detection of oxygen [IMP]
- erythrophore differentiation [IMP]
- glutathione metabolic process [IMP]
- heart development [IMP]
- hemopoiesis [IMP]
- hydrogen peroxide biosynthetic process [ISO]
- hydrogen peroxide metabolic process [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- iron ion homeostasis [IMP]
- liver development [IMP]
- locomotory behavior [IMP]
- mitochondrion organization [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of fibroblast proliferation [IDA]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- neuron development [IMP]
- oxidation-reduction process [ISO]
- oxygen homeostasis [ISO]
- positive regulation of nitric oxide biosynthetic process [IMP]
- post-embryonic development [IMP]
- protein homooligomerization [ISO]
- protein homotetramerization [ISO]
- regulation of blood pressure [IMP]
- regulation of catalytic activity [IMP]
- regulation of mitochondrial membrane potential [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- release of cytochrome c from mitochondria [IMP]
- removal of superoxide radicals [IDA, IMP, ISO]
- respiratory electron transport chain [IMP]
- response to activity [IMP]
- response to axon injury [IMP]
- response to drug [ISO]
- response to gamma radiation [IGI]
- response to hydrogen peroxide [IMP]
- response to hyperoxia [IMP]
- response to nutrient levels [ISO]
- response to oxidative stress [IGI, IMP]
- response to reactive oxygen species [IMP]
- response to superoxide [IMP, ISO]
- sensory perception of sound [IMP]
- superoxide anion generation [IMP]
- superoxide metabolic process [IMP, ISO]
- vasodilation [IMP]
- vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.
Glycolysis and apoptosis are considered major but independent pathways that are critical for cell survival. The activity of BAD, a pro-apoptotic BCL-2 family member, is regulated by phosphorylation in response to growth/survival factors. Here we undertook a proteomic analysis to assess whether BAD might also participate in mitochondrial physiology. In liver mitochondria, BAD resides in a functional holoenzyme complex together ... [more]
Nature Aug. 21, 2003; 424(6951);952-6 [Pubmed: 12931191]
Throughput
- Low Throughput
Curated By
- BioGRID